African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping

MC Campbell, SA Tishkoff - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

The evolution of human genetic and phenotypic variation in Africa

MC Campbell, SA Tishkoff - Current biology, 2010 - cell.com
Africa is the birthplace of modern humans, and is the source of the geographic expansion of
ancestral populations into other regions of the world. Indigenous Africans are characterized …

Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation

S Fan, JP Spence, Y Feng, MEB Hansen, J Terhorst… - Cell, 2023 - cell.com
We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

The genetic structure and history of Africans and African Americans

SA Tishkoff, FA Reed, FR Friedlaender, C Ehret… - science, 2009 - science.org
Africa is the source of all modern humans, but characterization of genetic variation and of
relationships among populations across the continent has been enigmatic. We studied 121 …

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

E Patin, M Lopez, R Grollemund, P Verdu, C Harmant… - Science, 2017 - science.org
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-
speaking populations remains largely unexplored. We generated genomic data for 1318 …

Inferring admixture histories of human populations using linkage disequilibrium

PR Loh, M Lipson, N Patterson, P Moorjani… - Genetics, 2013 - academic.oup.com
Long-range migrations and the resulting admixtures between populations have been
important forces shaping human genetic diversity. Most existing methods for detecting and …

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

BM Henn, CR Gignoux, M Jobin… - Proceedings of the …, 2011 - National Acad Sciences
Africa is inferred to be the continent of origin for all modern human populations, but the
details of human prehistory and evolution in Africa remain largely obscure owing to the …

Hybridization, ecological races and the nature of species: empirical evidence for the ease of speciation

J Mallet - … Transactions of the Royal Society B: Biological …, 2008 - royalsocietypublishing.org
Species are generally viewed by evolutionists as 'real'distinct entities in nature, making
speciation appear difficult. Charles Darwin had originally promoted a very different …

The computer program STRUCTURE does not reliably identify the main genetic clusters within species: simulations and implications for human population structure

ST Kalinowski - Heredity, 2011 - nature.com
One of the primary goals of population genetics is to succinctly describe genetic
relationships among populations, and the computer program STRUCTURE is one of the …

The dawn of human matrilineal diversity

DM Behar, R Villems, H Soodyall, J Blue-Smith… - The American Journal of …, 2008 - cell.com
The quest to explain demographic history during the early part of human evolution has been
limited because of the scarce paleoanthropological record from the Middle Stone Age. To …