Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains
body temperature during environmental temperature challenges and alters body …

Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …

Torpor is an energy-conserving state in which animals dramatically decrease their metabolic
rate and body temperature to survive harsh environmental conditions. Here, we report the …

Many environmental conditions can constrain the ability of animals to obtain sufficient food
energy, or transform that food energy into useful chemical forms. To survive extended …

Immune defense is energetically costly, and thus an effective response requires metabolic
adaptation of the organism to reallocate energy from storage, growth, and development …

Thermogenesis, the production of heat energy, in brown adipose tissue is a significant
component of the homeostatic repertoire to maintain body temperature during the challenge …

Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the
induction of the hypothermic and hypometabolic torpid state in hibernating mammals, we …

Mammalian hibernation presents a unique opportunity to study naturally occurring
neuroprotection. Hibernating ground squirrels undergo rapid and extreme physiological …

Three decades of animal studies have reproducibly shown that hypothermia is profoundly
cerebroprotective during or after a central nervous system (CNS) insult. The success of …

Mammals are often considered to be masters of homeostasis, with the ability to maintain a
constant internal milieu, despite marked changes in the environment; however, many …