Abstract l-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino
acid for leukemic cells, into ammonia and aspartate. Owing to its ability to inhibit protein …

L-asparaginase, an amidohydrolase that catalyses break down of L-asparagine into aspartic
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …

L-asparaginase is an enzyme used as a biopharmaceutical to treat acute lymphoblastic
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …

Introduction: The bacterial enzyme has gained more attention in therapeutic application
because of the higher substrate specificity and longer half-life. L-asparaginase is an …

Bacterial L-asparaginase (LA) is a chemotherapeutic drug that has remained mainstay of
cancer treatment for several decades. LA has been extensively used worldwide for the …

Abstract l-Asparaginase is an anti-cancer agent which prevents the proliferation of
cancerous cells by decreasing the level of asparagine in the blood. l-asparaginase from …

Over the past few years, there has been a surge in the industrial production of recombinant
enzymes from microorganisms due to their catalytic characteristics being highly efficient …

Cancer cells have an abnormally high requirement for the l-asparagine and cannot make
enough l-asparagine due to lack of l-asparagine synthetase. Consequently, administration …

L-Asparaginase (ASNase) is used in the treatment of acute lymphoblastic leukemia, being
produced and commercialized only from bacterial sources. Alternative Saccharomyces …

Abstract l-Asparaginase (3.5. 1.1) being antineoplastic in nature are used in the treatment of
acute lymphoblastic leukemia (ALL). However glutaminase activity is the cause of various …