Bone fragility in diabetes: novel concepts and clinical implications
Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus
S Khosla, P Samakkarnthai, DG Monroe… - Nature Reviews …, 2021 - nature.com
Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …
patients sustain fractures despite having higher levels of areal bone mineral density, as …
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
G Colleluori, DT Villareal - Experimental gerontology, 2021 - Elsevier
The number of adults 65 years and older is increasing worldwide and will represent the 20%
of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass …
of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass …
DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis
E Shevroja, FP Cafarelli, G Guglielmi, D Hans - Endocrine, 2021 - Springer
Osteoporosis, a disease characterized by low bone mass and alterations of bone
microarchitecture, leading to an increased risk for fragility fractures and, eventually, to …
microarchitecture, leading to an increased risk for fragility fractures and, eventually, to …
Bone quality in endocrine diseases: determinants and clinical relevance
Purpose Bone is one of the main targets of hormones and endocrine diseases are frequent
causes of secondary osteoporosis and fractures in real-world clinical practice. However …
causes of secondary osteoporosis and fractures in real-world clinical practice. However …
Vitamin D in osteosarcopenic obesity
Osteosarcopenic obesity is a unique clinical condition where low bone and muscle mass
coexist in individuals with obesity. Alterations in adipose tissue, skeletal muscle and bone …
coexist in individuals with obesity. Alterations in adipose tissue, skeletal muscle and bone …
Investigation of mechanical, material, and compositional determinants of human trabecular bone quality in type 2 diabetes
Context Increased bone fragility and reduced energy absorption to fracture associated with
type 2 diabetes (T2D) cannot be explained by bone mineral density alone. This study, for the …
type 2 diabetes (T2D) cannot be explained by bone mineral density alone. This study, for the …
Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study
AV Schwartz, JYC Backlund, IH de Boer… - The Lancet Diabetes & …, 2022 - thelancet.com
Background Type 1 diabetes is associated with lower bone mineral density (BMD) and
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …
New emerging biomarkers for bone disease: sclerostin and Dickkopf-1 (DKK1)
AS Dincel, NR Jørgensen… - Calcified Tissue …, 2023 - Springer
A healthy skeleton depends on a continuous renewal and maintenance of the bone tissue.
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …
Biochemical markers of bone fragility in patients with diabetes
C Meier, R Eastell, DD Pierroz, NE Lane… - The Journal of …, 2023 - academic.oup.com
Context The risk of fragility fractures is increased in both type 1 and type 2 diabetes.
Numerous biochemical markers reflecting bone and/or glucose metabolism have been …
Numerous biochemical markers reflecting bone and/or glucose metabolism have been …