N-Functionalized Pyridinium Salts: A New Chapter for Site-Selective Pyridine C–H Functionalization via Radical-Based Processes under Visible Light Irradiation

M Kim, Y Koo, S Hong - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus The radical-mediated C–H functionalization of pyridines has attracted
considerable attention as a powerful tool in synthetic chemistry for the direct …

meta‐Selective C−H Functionalization of Pyridines

H Cao, Q Cheng, A Studer - Angewandte Chemie International …, 2023 - Wiley Online Library
The pyridine moiety is an important core structure for a variety of drugs, agrochemicals,
catalysts, and functional materials. Direct functionalization of C− H bonds in pyridines is a …

Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines

H Cao, Q Cheng, A Studer - Science, 2022 - science.org
Carbon-hydrogen (C− H) functionalization of pyridines is a powerful tool for the rapid
construction and derivatization of many agrochemicals, pharmaceuticals, and materials …

Electrochemical meta-C–H sulfonylation of pyridines with nucleophilic sulfinates

S Qin, M Yang, M Xu, ZH Peng, J Cai, S Wang… - Nature …, 2024 - nature.com
Considering the indispensable significance and utilities of meta-substituted pyridines in
medicinal, chemical as well as materials science, a direct meta-selective C–H …

β-Selective reductive coupling of alkenylpyridines with aldehydes and imines via synergistic lewis acid/photoredox catalysis

KN Lee, Z Lei, MY Ngai - Journal of the American Chemical …, 2017 - ACS Publications
Umpolung (polarity reversal) strategies of aldehydes and imines have dramatically
expanded the scope of carbonyl and iminyl chemistry by facilitating reactions with non …

Visible-light-driven C4-selective alkylation of pyridinium derivatives with alkyl bromides

S Jung, S Shin, S Park, S Hong - Journal of the American …, 2020 - ACS Publications
Reported herein is a general strategy for the photochemical cross-coupling between N-
amidopyridinium salts and various alkyl bromides under photocatalyst-free conditions …

Selective functionalization of pyridines via heterocyclic phosphonium salts

MC Hilton, RD Dolewski, A McNally - Journal of the American …, 2016 - ACS Publications
Methods that directly functionalize pyridines are in high demand due to their presence in
pharmaceuticals, agrochemicals, and materials. A reaction that selectively transforms the 4 …

Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis

H Choi, GR Mathi, S Hong, S Hong - Nature Communications, 2022 - nature.com
A catalytic method for the enantioselective and C4-selective functionalization of pyridine
derivatives is yet to be developed. Herein, we report an efficient method for the asymmetric β …

Recent applications of trifluoromethanesulfonic anhydride in organic synthesis

Q Qin, Z Cheng, N Jiao - Angewandte Chemie, 2023 - Wiley Online Library
Trifluoromethanesulfonic anhydride has been widely used in synthetic organic chemistry,
not only for the conversion of various oxygen‐containing compounds to the triflates, but also …

Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis

CH Ma, Y Ji, J Zhao, X He, ST Zhang, YQ Jiang… - Chinese Journal of …, 2022 - Elsevier
A general transition-metal-free photoinduced acetalation-pyridylation of alkenes using
diethoxyacetic acid and cyanopyridine was developed under mild conditions. By employing …