Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates

T Saturday, N van Doremalen - Current Opinion in Virology, 2023 - Elsevier
The continued pressure of COVID-19 on public health worldwide underlines the need for a
better understanding of the mechanisms of disease caused by severe acute respiratory …

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

Y Ji, Q Zhang, L Cheng, J Ge, R Wang, M Fang… - Frontiers in …, 2022 - frontiersin.org
Monoclonal antibodies (mAbs) targeting the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) spike protein have demonstrated clinical efficacy in preventing or treating …

Symptom propagation in respiratory pathogens of public health concern: a review of the evidence

P Asplin, R Mancy, T Finnie… - Journal of the …, 2024 - royalsocietypublishing.org
Symptom propagation occurs when the symptom set an individual experiences is correlated
with the symptom set of the individual who infected them. Symptom propagation may …

Aerosol Particle Size Influences the Infectious Dose and Disease Severity in a Golden Syrian Hamster Model of Inhalational COVID-19

JA Boydston, J Biryukov, JJ Yeager… - Journal of Aerosol …, 2023 - liebertpub.com
Background: Significant evidence suggests that SARS-CoV-2 can be transmitted via
respiratory aerosols, which are known to vary as a function of respiratory activity. Most …

Animal models for the study of SARS-CoV-2–induced respiratory disease and pathology

JA Dillard, SA Martinez, JJ Dearing… - Comparative …, 2023 - ingentaconnect.com
Emergence of the betacoronavirus SARS-CoV-2 has resulted in a historic pandemic, with
millions of deaths worldwide. An unprecedented effort has been made by the medical …

Comparison of Dose–Response Relationships for Two Isolates of SARS-CoV-2 in a Nonhuman Primate Model of Inhalational COVID-19

PA Dabisch, JS Sanjak, JA Boydston… - Journal of Aerosol …, 2022 - liebertpub.com
Background: As the COVID-19 pandemic has progressed, numerous variants of SARS-CoV-
2 have arisen, with several displaying increased transmissibility. Methods: The present study …

Compartmentalized SARS-CoV-2 Replication in the Upper vs Lower Respiratory Tract After Intranasal Inoculation or Aerosol Exposure

RJ Fischer, T Bushmaker, BN Williamson… - The Journal of …, 2024 - academic.oup.com
Nonhuman primate models are essential for the development of vaccines and antivirals
against infectious diseases. Rhesus macaques are a widely utilized infection model for …

[HTML][HTML] Airborne Transmission and Control of Influenza and Other Respiratory Pathogens

JB de Mesquita - Infectious Diseases Annual Volume 2022, 2022 - intechopen.com
Despite uncertainty about the specific transmission risk posed by airborne, spray-borne, and
contact modes for influenza, SARS-CoV-2, and other respiratory viruses, there is evidence …