Innate immunity driven by pattern recognition receptor (PRR) protects the host from invading
pathogens. Aquatic animals like fish where the adaptive immunity is poorly developed …

Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely
related to the intestinal microbiota. Many reports and clinical studies have shown that …

The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes
nucleotide-dependent activation of the NLR downstream of pathogen-or danger-associated …

Receptor-interacting serine/threonine kinase 2 (RIPK2) is a vital immunomodulator that
plays critical roles in nucleotide-binding oligomerization domain 1 (NOD1), NOD2, and Toll …

Signals arising from bacterial infections are detected by pathogen recognition receptors
(PRRs) and are transduced by specialized adapter proteins in mammalian cells. The …

NOD2/RIPK2 signalling plays essential role in the modulation of innate and adaptive
immunity in mammals. In this study, NOD2 was functionally characterized in zebrafish …

Nucleotide‐binding and oligomerization domain (NOD)‐like receptors (NLR s) are a group
of intracellular pathogen recognition receptors (PRR s) that play key roles in pathogen …

The skin mucus of fish is equipped with immunological and antimicrobial peptides that
confer protection against invading pathogens. The skin mucus has been studied in fish …

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), the first line of
defense, are the cytosolic pattern recognition receptors (PRRs) that regulate the …

Inhibitors of apoptosis (IAPs) proteins are critical regulators of innate immune signaling
pathways and therefore have potential as drug targets. X-linked IAP (XIAP) and cellular IAP1 …