Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Driven by rapidly evolving technologies in next-generation sequencing, alternative splicing
has emerged as a crucial layer in gene expression, greatly expanding protein diversity and …

Cell-type-specific splicing generates numerous alternatively spliced transcripts playing
important roles for organ development and homeostasis, but only a few tissue-specific …

Background—Cardiomyocytes are rich in mitochondria which are situated in spatially
distinct subcellular regions, including those under the plasma membrane, subsarcolemmal …

Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-
binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; …

Alternative splicing (AS) defects that adversely affect gene expression and function have
been identified in diabetic hearts; however, the mechanisms responsible are largely …

In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which
are intimately involved in every step of RNA biology, including transcription, editing, splicing …

The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1
gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of …

Background In January 2005, Rasulov et al. originally published “First experience in the use
of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin …

The regulation of adhesion and growth is important for epithelial function and dysfunction. β-
catenin (armadillo in Drosophila) is the prototype of a multifunctional molecule that regulates …