Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …
challenges facing cardiovascular medicine today. Despite being the most common form of …
[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …
The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research
TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
ACE2 in the era of SARS-CoV-2: controversies and novel perspectives
F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …
Murine models of heart failure with preserved ejection fraction: a “fishing expedition”
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
Angiotensin-(1–7)
RA Santos - Hypertension, 2014 - Am Heart Assoc
Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …
Angiotensin‐converting enzyme 2: the first decade
NE Clarke, AJ Turner - International journal of hypertension, 2012 - Wiley Online Library
The renin‐angiotensin system (RAS) is a critical regulator of hypertension, primarily through
the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin …
the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin …
Physiology of kidney renin
H Castrop, K Höcherl, A Kurtz… - Physiological …, 2010 - journals.physiology.org
The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …
is relevant under both physiological and pathophysiological settings. The kidney is the only …