Enzymatic carbon–sulfur bond formation in natural product biosynthesis
KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …
Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System
L Tan, SR Li, B Jiang, XM Hu, S Li - Frontiers in microbiology, 2018 - frontiersin.org
Staphylococcus aureus can cause numerous different diseases, which has been attributed
to its large repertoire of virulence factors, many of which are under the control of the …
to its large repertoire of virulence factors, many of which are under the control of the …
Affinity-based capture and identification of protein effectors of the growth regulator ppGpp
The nucleotide ppGpp is a highly conserved regulatory molecule in bacteria that helps tune
growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth …
growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth …
Regulation of virulence in Staphylococcus aureus: molecular mechanisms and remaining puzzles
The agr locus encodes a quorum-sensing (QS) circuit required for the virulence of a
spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for …
spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for …
ppGpp coordinates nucleotide and amino-acid synthesis in E. coli during starvation
Summary (p) ppGpp is a nucleotide messenger universally produced in bacteria following
nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several …
nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several …
Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development
Bacteria use a process called quorum sensing to communicate and orchestrate collective
behaviours, including virulence factor secretion and biofilm formation. Quorum sensing …
behaviours, including virulence factor secretion and biofilm formation. Quorum sensing …
Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages
JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
Quorum-sensing, intra-and inter-species competition in the staphylococci
In Gram-positive bacteria such as Staphylococcus aureus and the coagulase-negative
staphylococci (CoNS), the accessory gene regulator (agr) is a highly conserved but …
staphylococci (CoNS), the accessory gene regulator (agr) is a highly conserved but …
Expanding the Landscape of Noncanonical Amino Acids in RiPP Biosynthesis
BA Johnson, KA Clark, LB Bushin… - Journal of the …, 2024 - ACS Publications
Advancements in DNA sequencing technologies and bioinformatics have enabled the
discovery of new metabolic reactions from overlooked microbial species and metagenomic …
discovery of new metabolic reactions from overlooked microbial species and metagenomic …
Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis
In Staphylococcus aureus, virulence is under the control of a quorum sensing (QS) circuit
encoded in the accessory gene regulator (agr) genomic locus. Key to this pathogenic …
encoded in the accessory gene regulator (agr) genomic locus. Key to this pathogenic …