Type 1 diabetes
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
Differentiation of diabetes by pathophysiology, natural history, and prognosis
The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …
Diabetes, and the American Association of Clinical Endocrinologists convened a research …
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
MA Atkinson, RG Mirmira - Cell Metabolism, 2023 - cell.com
Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
Introducing the endotype concept to address the challenge of disease heterogeneity in type 1 diabetes
M Battaglia, S Ahmed, MS Anderson… - Diabetes …, 2020 - Am Diabetes Assoc
The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered
relatively straightforward. Recently, however, there is increasing awareness that within this …
relatively straightforward. Recently, however, there is increasing awareness that within this …
Insulitis and β-cell mass in the natural history of type 1 diabetes
M Campbell-Thompson, A Fu, JS Kaddis… - Diabetes, 2016 - Am Diabetes Assoc
Descriptions of insulitis in human islets throughout the natural history of type 1 diabetes are
limited. We determined insulitis frequency (the percent of islets displaying insulitis to total …
limited. We determined insulitis frequency (the percent of islets displaying insulitis to total …
Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis
Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes
exist. Our aim was to use a unique collection of pancreas samples recovered soon after …
exist. Our aim was to use a unique collection of pancreas samples recovered soon after …
α cell function and gene expression are compromised in type 1 diabetes
Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …
C-peptide long after disease onset but develop an inadequate glucagon response to …
Type 1 diabetes—a clinical perspective
L Kahanovitz, PM Sluss, SJ Russell - Point of care, 2017 - journals.lww.com
Type 1 diabetes mellitus is a disorder of glucose regulation characterized by autoimmune
destruction of the insulin-producing pancreatic β-cells and the need for lifelong insulin …
destruction of the insulin-producing pancreatic β-cells and the need for lifelong insulin …
Partners in crime: beta-cells and autoimmune responses complicit in type 1 diabetes pathogenesis
E Toren, KLS Burnette, RR Banerjee… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …