Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin
facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous
system produce an enormous amount of plasma membrane during the myelination process …

Helix–helix interactions play a central role in the folding and assembly of integral α-helical
membrane proteins and are fundamentally dictated by the amino acid sequence of the TM …

In accordance with their manifold tasks, various dysfunctions of mitochondria are critically
involved in a large number of diseases and the aging process. This has inspired …

The myelin sheath is an essential, multilayered membrane structure that insulates axons,
enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein …

Beyond finding individual genes that are involved in medical disorders, an important
challenge is the integration of sets of disease genes with the complexities of basic biological …

Pelizaeus–Merzbacher disease (PMD) is an X-linked disorder caused by mutations in the
PLP1 gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD …

Pelizaeus–Merzbacher disease (PMD) is a recessive X-linked dysmyelinating disorder of
the central nervous system (CNS). The most frequent cause of PMD is a genomic duplication …

Pelizaeus-Merzbacher disease (PMD) represents a group of disorders known as
hypomyelinating leukodystrophies, which are characterized by abnormal development and …