Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Zebrafish as an emerging model for studying complex brain disorders

AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature

DS Grayson, DA Fair - Neuroimage, 2017 - Elsevier
The development of human cognition results from the emergence of coordinated activity
between distant brain areas. Network science, combined with non-invasive functional …

Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan

C Ecker, SY Bookheimer, DGM Murphy - The Lancet Neurology, 2015 - thelancet.com
Over the past decade, in-vivo MRI studies have provided many invaluable insights into the
neural substrates underlying autism spectrum disorder (ASD), which is now known to be …

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

ML Estes, AK McAllister - Nature Reviews Neuroscience, 2015 - nature.com
Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

Corticostriatal connectivity and its role in disease

GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

[HTML][HTML] Reconceptualizing functional brain connectivity in autism from a developmental perspective

LQ Uddin, K Supekar, V Menon - Frontiers in human neuroscience, 2013 - frontiersin.org
While there is almost universal agreement amongst researchers that autism is associated
with alterations in brain connectivity, the precise nature of these alterations continues to be …

Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition

W Mandy, MC Lai - Journal of Child Psychology and Psychiatry, 2016 - Wiley Online Library
Background Although autism spectrum condition (ASC) is strongly genetic in origin,
accumulating evidence points to the critical roles of various environmental influences on its …

[HTML][HTML] Altered functional and structural brain network organization in autism

JD Rudie, JA Brown, D Beck-Pancer, LM Hernandez… - NeuroImage …, 2013 - Elsevier
Structural and functional underconnectivity have been reported for multiple brain regions,
functional systems, and white matter tracts in individuals with autism spectrum disorders …