Blood coagulation, skin-barrier formation, hardening of the fertilization envelope,
extracellular-matrix assembly and other important biological processes are dependent on …

Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the
post-translational modification of proteins by the formation of isopeptide bonds. This occurs …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

The transforming proteins of acute promyelocytic leukaemias (APL) are fusions of the
promyelocytic leukaemia (PML) and the promyelocytic leukaemia zinc-finger (PLZF) proteins …

DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional
silencing in cancer. The molecular mechanisms underlying the specificity of methylation are …

Low concentrations of As2O3 (≤ 1 μmol/L) induce long-lasting remission in patients with
acute promyelocytic leukemia (APL) without significant myelosuppressive side effects …

Transglutaminases form a family of proteins that have evolved for specialized functions such
as protein crosslinking in haemostasis, semen coagulation, or keratinocyte cornified …

Background. Retinoids, which are derivatives of vitamin A, induce differentiation of acute
promyelocytic leukemia (APL) cells in vitro and in patients However, APL cells develop …

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations,
invariably involving the retinoic acid receptor α (RARα) gene fused to one of several distinct …

Epigenetic modifications regulate developmental genes involved in stem cell identity and
lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing …