Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Reverse genetics in model organisms such as Drosophila melanogaster, Arabidopsis
thaliana, zebrafish and rats, efficient genome engineering in human embryonic stem and …

Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection
of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

A method for stimulating the differentiation of human pluripotent stem cells into kidney
lineages remains to be developed. Most cells in kidney are derived from an embryonic germ …

The combination of induced pluripotent stem cell (iPSC) technology and targeted gene
modification by homologous recombination (HR) represents a promising new approach to …

Human induced pluripotent stem cells (iPSCs) bearing monogenic mutations have great
potential for modeling disease phenotypes, screening candidate drugs, and cell …

Background The ability to deliver a gene of interest into a specific cell type is an essential
aspect of biomedical research. Viruses can be a useful tool for this delivery, particularly in …

The clinical use of human pluripotent stem cells and their derivatives is limited by the
rejection of transplanted cells due to differences in their human leukocyte antigen (HLA) …