N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical
transformation which provides routes for the synthesis of a wide range of pharmaceuticals …

Drugs are metabolized within the liver (pH 7.4) by phase I and phase II metabolism. During
the process, reactive metabolites can be formed that react covalently with biomolecules and …

Synthesis of drug metabolites, which often have complex structures, is an integral step in the
evaluation of drug candidate metabolism, pharmacokinetic (PK) properties, and safety …

Understanding the metabolism of pharmaceutical compounds is a fundamental prerequisite
for ensuring their safety and efficacy in clinical use. However, conventional methods for …

Parkinson's disease is a neurodegenerative disorder associated with oxidative stress and
the death of melanin-containing neurons of the substantia nigra. Epidemiological evidence …

Redox reactions are integral parts of many cellular processes. They are therefore
extensively studied in vitro and in vivo. Electrochemistry (EC) represents a purely …

Carbon-nitrogen bond cleavage in the form of N-dealkylation is an important chemical
transformation which provides routes for the synthesis of a wide range of pharmaceuticals …