Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …

Nutrition exerts considerable effects on health, and dietary interventions are commonly used
to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic …

The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

Methionine is an essential amino acid with many key roles in mammalian metabolism such
as protein synthesis, methylation of DNA and polyamine synthesis. Restriction of methionine …

Amino acid metabolism plays important roles in tumor biology and tumor therapy.
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …

Most tumors display oncogene-driven reprogramming of several metabolic pathways, which
are crucial to sustain their growth and proliferation. In recent years, both dietary and …

The way cancer cells utilize nutrients to support their growth and proliferation is determined
by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the …

Introduction: All tested cancer cell types are methionine dependent in that the cells arrest
and eventually die when deprived of methionine, a condition that is generally nontoxic to …

Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …