Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as
phytic acid or IP6, with their biological activities received much attention for their role in …

Myo-inositol is a natural polyol, the most abundant among the nine possible structural
isomers available in living organisms. Inositol confers some distinctive traits that allow for a …

Obesity and obesity-induced metabolic dysfunctions are significant risk factors for
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …

The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …

Inositol pyrophosphates have been implicated in cellular signaling and membrane
trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases …

Background and aims Atherosclerotic cardiovascular diseases are the leading cause of
death. Apolipoprotein AI (apoA-I) mediates cholesterol efflux to lower the risks of …

Initial studies on the inositol phosphates metabolism were enabled by the social amoeba
Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP 6 also …

Phenolic compounds possess significant biological activity. Several pieces of research
emphasize the medicinal importance of phenolic compounds, including diabetes. The …

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease in the United States and globally. The currently understood model of pathogenesis …