Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Simple Summary Mucociliary clearance constitutes an innate lung defense mechanism that
is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways …

In recent years, sodium p-perfluorous nonenoxybenzene sulfonate (OBS) has emerged as a
substitute for PFOS with large demand and application in the Chinese market. However, little …

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for
peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA …

The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to
several distinct cellular compartments, including the cilium. PKD2 mutations cause …

The mammalian Hedgehog (Hh) signaling pathway is required for development and for
maintenance of adult stem cells, and overactivation of the pathway can cause …

Ciliary membrane composition is controlled by transition zone (TZ) proteins such as
RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse …

The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of
recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1) …

ARPKD is a genetically inherited kidney disease that manifests by bilateral enlargement of
cystic kidneys and liver fibrosis. It shows a range of severity, with 30% of individuals dying …

Intraflagellar transport (IFT) is the bi-directional movement of particles along the length of
cilia/flagella (terms used interchangeably here)(reviewed in Rosenbaum and Witman, 2002; …