Two new elaiophylin derivatives, efomycins K (1) and L (2), and five known elaiophylin
derivatives (3–7) were isolated from the termite-associated Streptomyces sp. M56. The …

Bafilomycins are an important subgroup of polyketides with diverse biological activities and
possible applications as specific inhibitors of vacuolar H+-ATPase. However, the general …

A convergent synthesis of bafilomycin A1, a potent inhibitor of V‐type ATPases, is presented.
The synthesis relies on the zinc triflate mediated diastereoselective addition of a complex …

Nocardia are opportunistic human pathogens that can cause a range of debilitating and
difficult to treat infections of the lungs, brain, skin, and soft tissues. Despite their close …

A highly stereocontrolled total synthesis of the 18-membered macrolide (+)-concanamycin F,
a potent inhibitor of vacuolar ATPases, is described that proceeds in 5.8% yield over 26 …

Bafilomycin A1 (1; Scheme 1) was first isolated in 1983 from a culture of Streptomyces
griseus sp. sulphurus [1] and classified as a member of the plecomacrolide family of natural …

Small molecule inhibitors against protein geranylgeranyltransferase-I such as P61A6 have
been shown to inhibit proliferation of a variety of human cancer cells and exhibit antitumor …

An efficient synthesis of the C13− C25 fragment is described for 24-demethylbafilomycin C1,
a new member of the plecomacrolide family isolated from fermentation broth of …

Abstract The 9‐methoxy‐9‐borabicyclo [3.3. 1] nonane‐based B‐alkyl Suzuki–Miyaura
cross‐coupling reaction (the 9‐MeO‐9‐BBN variant) has been efficiently performed by using …

A total, stereoselective synthesis of the naturally occurring, cytotoxic macrolide FD‐891 and
of its non‐natural (Z)‐C12 isomer is described. Three fragments of the main carbon chain …