EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Long axial field of view PET scanners: a road map to implementation and new possibilities
In this contribution, several opportunities and challenges for long axial field of view (LAFOV)
PET are described. It is an anthology in which the main issues have been highlighted. A …
PET are described. It is an anthology in which the main issues have been highlighted. A …
Forward to the past: the case for quantitative PET imaging
AA Lammertsma - Journal of Nuclear Medicine, 2017 - Soc Nuclear Med
PET was developed in the 1970s as an in vivo method to measure regional
pathophysiologic processes. In the 1990s the focus moved to the detection of local …
pathophysiologic processes. In the 1990s the focus moved to the detection of local …
Insight into the Development of PET Radiopharmaceuticals for Oncology
While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …
closely follows that of traditional drug development, there are several key considerations in …
Value of 18F–FDG PET/CT for predicting EGFR mutations and positive ALK expression in patients with non-small cell lung cancer: a retrospective analysis of 849 …
Z Lv, J Fan, J Xu, F Wu, Q Huang, M Guo, T Liao… - European Journal of …, 2018 - Springer
Purpose Epidermal growth factor receptor (EGFR) mutations and the anaplastic lymphoma
kinase (ALK) rearrangement are the two most common druggable targets in non-small cell …
kinase (ALK) rearrangement are the two most common druggable targets in non-small cell …
Positron emission tomographic imaging in drug discovery
Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …
technique, especially for central nervous system (CNS) and oncological disorders. Currently …
Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging
The development of methods to accurately quantify cell-surface receptors in living tissues
would have a seminal impact in oncology. For example, accurate measures of receptor …
would have a seminal impact in oncology. For example, accurate measures of receptor …
A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management
X Sun, Z Xiao, G Chen, Z Han, Y Liu, C Zhang… - Science translational …, 2018 - science.org
Tumor heterogeneity and changes in epidermal growth factor receptor (EGFR) mutation
status over time challenge the design of effective EGFR tyrosine kinase inhibitor (TKI) …
status over time challenge the design of effective EGFR tyrosine kinase inhibitor (TKI) …
Molecular imaging in cancer drug development
SJH Waaijer, IC Kok, B Eisses… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Development of new oncology drugs has increased since the improved understanding of
cancer's complex biology. The oncology field has become the top therapeutic research area …
cancer's complex biology. The oncology field has become the top therapeutic research area …
Role of [18F]FDG PET in prediction of KRAS and EGFR mutation status in patients with advanced non-small-cell lung cancer
C Caicedo, MJ Garcia-Velloso, MD Lozano… - European journal of …, 2014 - Springer
Purpose The tumour molecular profile predicts the activity of epidermal growth factor
receptor (EGFR) inhibitors in non-small-cell lung cancer (NSCLC). However, tissue …
receptor (EGFR) inhibitors in non-small-cell lung cancer (NSCLC). However, tissue …