Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

Chronic pain is one of the most prevalent health problems in our modern world, with millions
of people debilitated by conditions such as back pain, headache and arthritis. To address …

Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Fibromyalgia syndrome is mainly characterized by pain, fatigue, and sleep disruption. The
etiology of fibromyalgia is still unclear: if central sensitization is considered to be the main …

Objective Fibromyalgia (FM) is considered to be the prototypical central chronic pain
syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple …

Pain is a highly complex and individual experience with biological, psychological and social
(biopsychosocial) contributions. Pain is associated with activity within the nervous system …

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of
central nervous system pain mechanisms (for example, loss of descending analgesic activity …

Mechanisms underlying chronic pain differ from those underlying acute pain. In chronic pain
states, central nervous system (CNS) factors appear to play particularly prominent roles. In …

In this review, we present data from functional, structural, and molecular imaging studies in
patients and animals supporting the notion that it might be time to reconsider chronic pain as …