Advancements in nanoparticle-based treatment approaches for skin cancer therapy

L Zeng, BHJ Gowda, MG Ahmed, MAS Abourehab… - Molecular Cancer, 2023 - Springer
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a
burden on global health and the economy. The enormously rising environmental changes …

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer

Z Liu, N Parveen, U Rehman, A Aziz, A Sheikh… - Molecular Cancer, 2023 - Springer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy

P Kesharwani, A Sheikh, MAS Abourehab… - Journal of Drug Delivery …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) is one major type of cancer for which there has been
no effective therapy to date. An important reason for it being the lack of expression of …

Immunoliposomes as an emerging nanocarrier for breast cancer therapy

N Parveen, MAS Abourehab, R Shukla… - European Polymer …, 2023 - Elsevier
The most prevalent non-cutaneous carcinoma in women and the second most prevalent
tumour-related condition is breast cancer. There are significant therapeutic choices for …

Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond

X Fu, U Rehman, L Wei, ZS Chen… - Drug Resistance …, 2023 - Elsevier
To develop next-generation nanomedicine, theranostic nanotherapeutic strategies are
increasingly being emphasized. In recent years, it is observed that the effective lifetime of …

Polymeric micelles assisted combinatorial therapy: Is it new hope for pancreatic cancer?

U Rehman, MAS Abourehab, A Alexander… - European Polymer …, 2023 - Elsevier
Pancreatic cancer (PC) is a fatal disease that has a 5-year survival rate of less than 9%. It is
expected to rank second in cancer-related deaths across the United States by 2030. Out of …

Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents

S Faazil, MS Malik, SA Ahmed, RI Alsantali, P Yedla… - Bioorganic …, 2022 - Elsevier
The quest for new antifungal and antitubercular drugs is a need of the hour because of
morbid co-pathogenesis and an increase in immunocompromised patients. One of the ways …

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

MS Malik, RI Alsantali, QMS Jamal, ZS Seddigi… - Frontiers in …, 2022 - frontiersin.org
An efficient atom-economical synthetic protocol to access new imidazole-based N-
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …

Recent advancements on the synthesis and biological significance of pipecolic acid and its derivatives

MM Al-Rooqi, EU Mughal, QA Raja, RJ Obaid… - Journal of Molecular …, 2022 - Elsevier
Pipecolic acids are cyclic non-protein amino acids serving as precursors for the biosynthesis
of biological metabolites. Structurally, the six-membered cyclic motif consists of five-carbons …

The applications of β‐keto amides for heterocycle synthesis

X Wu, W Li - Journal of Heterocyclic Chemistry, 2022 - Wiley Online Library
Abstract β‐Keto amides have multiple nucleophilic and electrophilic reaction sites within
their molecular structures, which make them excellent building blocks for the construction of …