Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen
species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …

The cell cycle represents a series of tightly integrated events that allow the cell to grow and
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …

Purpose BRCA-associated cancers have increased sensitivity to poly (ADP-ribose)
polymerase inhibitors (PARPis). This single arm, non-randomised, multicentre phase II trial …

Chemical compounds that interfere with an enzymatic function of kinases are useful for
gaining insight into the complicated biochemical processes in mammalian cells. Cyclin …

Despite promising preclinical studies with the cyclin-dependent kinase inhibitor flavopiridol
in chronic lymphocytic leukemia (CLL) and other diseases, previous clinical trials with this …

The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …

Purpose Patients with chronic lymphocytic leukemia (CLL) with high-risk genomic features
achieve poor outcomes with traditional therapies. A phase I study of a pharmacokinetically …

Breast cancers expressing estrogen receptor α, progesterone receptor, or the human
epidermal growth factor receptor 2 (HER2) proto-oncogene account for approximately 90 …