Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

[HTML][HTML] A new perspective on lipid research in age-related macular degeneration

EM van Leeuwen, E Emri, BMJ Merle, JM Colijn… - Progress in retinal and …, 2018 - Elsevier
There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

An Aboriginal Australian genome reveals separate human dispersals into Asia

M Rasmussen, X Guo, Y Wang, KE Lohmueller… - Science, 2011 - science.org
We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock
of hair donated by an Aboriginal man from southern Western Australia in the early 20th …

The molecular basis of human retinal and vitreoretinal diseases

W Berger, B Kloeckener-Gruissem… - Progress in retinal and eye …, 2010 - Elsevier
During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

Vascular endothelial growth factor a in intraocular vascular disease

JW Miller, J Le Couter, EC Strauss, N Ferrara - Ophthalmology, 2013 - Elsevier
The vascular beds supplying the retina may sustain injury as a result of underlying disease
such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and …

Vascular endothelial growth factor in eye disease

JS Penn, A Madan, RB Caldwell, M Bartoli… - Progress in retinal and …, 2008 - Elsevier
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Molecular pathology of age-related macular degeneration

X Ding, M Patel, CC Chan - Progress in retinal and eye research, 2009 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Stem cells in retinal regeneration: past, present and future

CM Ramsden, MB Powner, AJF Carr… - …, 2013 - journals.biologists.com
Stem cell therapy for retinal disease is under way, and several clinical trials are currently
recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem …

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

AM Newman, NB Gallo, LS Hancox, NJ Miller… - Genome medicine, 2012 - Springer
Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …