Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies

WF Zuo, Q Pang, X Zhu, QQ Yang, Q Zhao… - Journal of Hematology & …, 2024 - Springer
Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

[HTML][HTML] Single nucleotide polymorphisms (SNPs) in prostate cancer: its implications in diagnostics and therapeutics

KS Allemailem, A Almatroudi, F Alrumaihi… - American journal of …, 2021 - ncbi.nlm.nih.gov
Prostate cancer is one of the most frequently diagnosed malignancies in developed
countries and approximately 248,530 new cases of prostate cancer are likely to be …

Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents

M Pal, U Nandi, D Mukherjee - European Journal of Medicinal Chemistry, 2018 - Elsevier
Ruthenium (Ru) complexes are known for their promising anticancer activity presumably
due to octahedral coordination geometry, slow ligand exchange rate, the range of different …

Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78

C Gong, X Hu, Y Xu, J Yang, L Zong, C Wang… - Anti-cancer …, 2020 - journals.lww.com
Human colorectal cancer (CRC), a highly malignant and metastatic carcinoma, is resistant to
many present anticancer therapies. The inhibition of tumor survival and growth through …

Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region

RS Manhas, SM Ahmad, KB Mir, A Ahmed… - Chemico-Biological …, 2022 - Elsevier
Biosynthesis of bisaryl preanthraquinone antibiotics by various microorganisms differs in
monomeric subunits as well as their dimerization positions leading to different …

Vimentin activation in early apoptotic cancer cells errands survival pathways during DNA damage inducer CPT treatment in colon carcinoma model

S Chakraborty, A Kumar, MM Faheem, A Katoch… - Cell Death & …, 2019 - nature.com
Epithelial to mesenchymal transitions (EMT) is a preparatory process for cancer cells to
attain motility and further metastasis to distant sites. Majority of DNA damaging drugs have …

Dual role of Par‐4 in abrogation of EMT and switching on mesenchymal to epithelial transition (MET) in metastatic pancreatic cancer cells

A Katoch, S Suklabaidya, S Chakraborty… - Molecular …, 2018 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a critical event that occurs during the invasion
and metastatic spread of cancer cells. Here, we conceive a dual mechanism of Par‐4 …

Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78

D Nayak, A Katoch, D Sharma, MM Faheem… - Breast cancer research …, 2019 - Springer
Purpose More than 90% of the breast cancer deaths occur due to the metastasis of the
cancer cells to secondary organ sites. Increased Glucose-regulated protein 78 (GRP78) …

The Glucose-Regulated Protein78 (GRP78) in the unfolded protein response (UPR) pathway: a potential therapeutic target for breast cancer

MM Sadeghipour, SA Torabizadeh… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Amongst all types of cancers, breast cancer is recognized as the most common cancer and a
principal cause of morbidity and mortality in women. Endoplasmic reticulum (ER) stress …

Natural podophyllotoxin analog 4DPG attenuates EMT and colorectal cancer progression via activation of checkpoint kinase 2

A Katoch, D Nayak, MM Faheem, A Kumar… - Cell Death …, 2021 - nature.com
Epithelial–mesenchymal transition (EMT) is critical for the metastatic dissemination of cancer
cells and contributes to drug resistance. In this study, we observed that epithelial colorectal …