Identification and characterization of forced degradation products of sertraline hydrochloride using UPLC, ultra-high-performance liquid chromatography-quadrupole …

P Grover, M Bhardwaj, D Mukherjee - Journal of Pharmaceutical and …, 2022 - Elsevier
The present study focused on the forced degradation behavior of sertraline hydrochloride
(SRT), selective serotonin reuptake inhibitor (SSRI). The drug was exposed to different …

Development and validation of liquid chromatography method for determination of Ibrutinib in finished dosage forms using quality by design approach

N Konduru, R Gundla, T Dongala… - Separation …, 2022 - Wiley Online Library
A simple, precise, linear, robust, accurate, and stability‐indicating liquid chromatography
method was developed and validated to determine Ibrutinib in finished solid dosage forms …

LC-MS/MS studies for identification and characterization of new forced degradation products of dabrafenib and establishment of their degradation pathway

P Grover, M Bhardwaj, L Mehta - Journal of Pharmaceutical and Biomedical …, 2021 - Elsevier
Dabrafenib (Tafinlar) is used for the treatment of patients with BRAF V600 mutation positive
unresectable or metastatic melanoma. Forced degradation study of the drug product and …

LC and LC-MS/MS studies for identification and characterization of degradation products of d-tubocurarine chloride

P Grover, S Maheshwari, K Nagarajan, L Mehta… - … of Pharmaceutical and …, 2023 - Elsevier
Forced degradation studies of d-tubocurarine (DTC) was carried out in hydrolytic (acidic,
alkaline and neutral), thermal, photolytic and oxidative degradation conditions as per …

Development and Validation of Fast and Sensitive RP-HPLC Stability-Indicating Method for Quantification of Piroxicam in Bulk Drug

V Chauhan, P Grover, M Bhardwaj… - Journal of …, 2025 - academic.oup.com
A simple, rapid, sensitive, and cost-effective green solvent-assisted reverse-phase high-
performance liquid chromatographic technique, coupled with a photodiode array detector …

Identification and Characterization of In Vitro Metabolites of Ibrutinib by Rat Liver Microsomes Using Ultra-Performance Liquid Chromatography Coupled with Tandem …

P Grover, M Bhardwaj, L Mehta… - Indian Journal of …, 2022 - search.ebscohost.com
Drug metabolism is very important in determining the safety and efficacy of the drug. We
worked towards this direction and designed a new strategy to study the in vitro metabolites …

Development and validation of robust, highly sensitive and stability-indicating RP-HPLC method for estimation of Deferasirox and its degradation products

T Shishodia, P Grover, K Nagarajan… - Journal of …, 2024 - academic.oup.com
A rapid, simple and highly sensitive stability-indicating reverse-phase high-performance
liquid chromatographic technique, coupled with a photodiode array detector, was developed …

[PDF][PDF] Development and validation of a stability-indicating method for neostigmine bromide: separation, identification and characterization of degradation product …

R Makkar, J Singh, M Bhardwaj, L Mehta… - Indian Journal of …, 2022 - academia.edu
Objectives: Forced degradation study of the drug product and drug substance is very much
important in drug development and drug discovery to establish the intrinsic stability and …

Development and Validation of Fast and Sensitive RP-HPLC Stability Indicating Method for Quantification of Teneligliptin in Bulk Drug

K Nagarajan, R Goel, A Bhardwaj… - Journal of …, 2024 - academic.oup.com
Teneligliptin (TEN) is a novel, third-generation DPP4 inhibitor (Dipeptidyl peptidase) used
for the treatment of Type 2 Diabetes Mellitus. A rapid, simple and highly sensitive stability …

[HTML][HTML] Isolation, identification and structural characterization of forced degradation products of mobocertinib using LC-MS/MS and NMR

S Mishra, A Chauhan, R Ramajayam - Results in Chemistry, 2024 - Elsevier
The main objective of this study is to develop and validate an LC-MS/MS stability-indicating
method for the isolation, identification, and characterization of forced degradation products …