During pregnancy, various immune effectors and molecules participating in the immune-
microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Objective Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, and its
pathogenetic mechanism is far from being understood. In this study, we aimed to explore the …

Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by progressive
inflammation and tissue damage in salivary glands and lacrimal glands. Our previous …

Societal factors associated with ocular surface diseases were mapped using a framework to
characterize the relationship between the individual, their health and environment. The …

The dysregulation of the JAK–STAT pathway is associated with various immune disorders.
Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK …

Background Primary Sjogren's syndrome (pSS) is a slowly progressive, inflammatory
autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal …

Sjögren syndrome (SS), the second most common autoimmune rheumatic disease, refers to
keratoconjunctivitis sicca and xerostomia resulting from immune lymphocytes that infiltrate …

Increased numbers of T follicular helper (Tfh) cells have been implicated in the development
of autoimmune diseases including primary Sjögren's syndrome (pSS), but how the Tfh cell …