The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in
young children (< 5years) and animals worldwide. RV primarily infects mature enterocytes in …

High-quality and complete reference genome assemblies are fundamental for the
application of genomics to biology, disease, and biodiversity conservation. However, such …

Background Tumor-associated macrophages (TAMs) play a key immunosuppressive role
that limits the ability of the immune system to fight cancer and hinder the antitumoral efficacy …

An influenza pandemic happens when a novel influenza A virus is able to infect and transmit
efficiently to a new, distinct host species. Although the exact timing of pandemics is …

Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen
infection. Ligand binding induces receptor dimerization which facilitates the recruitment of …

Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus
(DENV) infection, but the mechanisms underlying the exacerbated inflammation during …

Immune sentinel cells initiate immune responses to pathogens and tissue injury and are
capable of producing highly stimulus-specific responses. Insight into the mechanisms …

The immunological impact of individual commensal species within the microbiota is poorly
understood limiting the use of commensals to treat disease. Here, we systematically profile …

Cognate interaction between CD4+ effector memory T (T EM) cells and dendritic cells (DCs)
induces innate inflammatory cytokine production, resulting in detrimental autoimmune …