Design Principles, Sensing Mechanisms, and Applications of Highly Specific Fluorescent Probes for HOCl/OCl

D Wu, L Chen, Q Xu, X Chen… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Hypochlorous acid/hypochlorite (HOCl/OCl–), one of the most important
reactive oxygen species (ROS), plays vital roles in various physiological and pathological …

Small-molecule fluorescent probes for imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems

X Jiao, Y Li, J Niu, X Xie, X Wang… - Analytical …, 2018 - pubmed.ncbi.nlm.nih.gov
Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen,
and Sulfur Species in Biological Systems Small-Molecule Fluorescent Probes for Imaging and …

Photostable ratiometric pdot probe for in vitro and in vivo imaging of hypochlorous acid

L Wu, IC Wu, CC DuFort, MA Carlson… - Journal of the …, 2017 - ACS Publications
Developing probes for the detection of reactive oxygen species (ROS), a hallmark of many
pathophysiological process, is imperative to both understanding the precise roles of ROS in …

Lysosomal-targeted two-photon fluorescent probe to sense hypochlorous acid in live cells

B Zhang, X Yang, R Zhang, Y Liu, X Ren… - Analytical …, 2017 - ACS Publications
A two-photon reversible fluorescent probe L1 was designed and synthesized. The
fluorescence intensity of the probe solution was strong, while the fluorescence of the …

Highly specific and ultrasensitive two-photon fluorescence imaging of native HOCl in lysosomes and tissues based on thiocarbamate derivatives

B Zhu, P Li, W Shu, X Wang, C Liu, Y Wang… - Analytical …, 2016 - ACS Publications
Hypochlorous acid (HOCl) acts as a weak acid distributed mainly in acidic organelle
lysosomes of phagocytes and plays a crucial role in the immune defense. The elaborate …

Deformylation reaction-based probe for in vivo imaging of HOCl

P Wei, W Yuan, F Xue, W Zhou, R Li, D Zhang… - Chemical Science, 2018 - pubs.rsc.org
The detection of hypochlorous acid (HOCl) in vivo is vitally important because the local
concentration of HOCl is highly correlated with some diseases such as atherosclerosis and …

Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues

Z Mao, M Ye, W Hu, X Ye, Y Wang, H Zhang, C Li… - Chemical …, 2018 - pubs.rsc.org
HClO plays crucial roles in a wide range of biological and pathological processes. Recent
studies have revealed that the generation of HClO has close links with the wound healing …

Simultaneous Near‐Infrared and Two‐Photon In Vivo Imaging of H2O2 Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of …

B Dong, X Song, X Kong, C Wang, Y Tang… - Advanced …, 2016 - Wiley Online Library
DOI: 10.1002/adma. 201602939 due to the substantial spectral overlap between the probes
and their products after responding to the analytes.[9] Therefore, there is a great need to …

A ratiometric fluorescent probe for detecting hypochlorite in the endoplasmic reticulum

JT Hou, HS Kim, C Duan, MS Ji, S Wang… - Chemical …, 2019 - pubs.rsc.org
A colorimetric and fluorescent probe ER-ClO was presented in this work to detect cellular
hypochlorite with high selectivity and sensitivity. With an organelle targeting unit, ER-ClO …

Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

MJ Davies - Pharmacology & Therapeutics, 2021 - Elsevier
Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …