Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)

FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

S100 proteins in Alzheimer's disease

JS Cristóvão, CM Gomes - Frontiers in Neuroscience, 2019 - frontiersin.org
S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Amyloid fibril systems reduce, stabilize and deliver bioavailable nanosized iron

Y Shen, L Posavec, S Bolisetty, FM Hilty… - Nature …, 2017 - nature.com
Iron-deficiency anaemia (IDA) is a major global public health problem. A sustainable and
cost-effective strategy to reduce IDA is iron fortification of foods, but the most bioavailable …

An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice

Z Chen, X Mu, Z Han, S Yang, C Zhang… - Journal of the …, 2019 - ACS Publications
Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging
depth and low interferences from tissue scattering/autofluorescence and probe …

Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide

P Faller, C Hureau, O Berthoumieu - Inorganic chemistry, 2013 - ACS Publications
Aggregation of amyloid-β (Aβ) by self-assembly into oligomers or amyloids is a central event
in Alzheimer's disease. Coordination of transition-metal ions, mainly copper and zinc, to Aβ …

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

ND Solovyev - Journal of inorganic biochemistry, 2015 - Elsevier
Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Suprareceptors emerging from click chemistry: Comparing the triazole based scaffolds of calixarenes, cyclodextrins, cucurbiturils and pillararenes

VVS Mummidivarapu, R Joseph, CP Rao… - Coordination Chemistry …, 2023 - Elsevier
Rapid, reliable, and unbiased detection and quantification of important analytes have drawn
rising attention because of the dire need to understand the environmental and the …

Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals

A Taglialegna, S Navarro, S Ventura, JA Garnett… - PLoS …, 2016 - journals.plos.org
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often
contains proteins. The spatial organization and the molecular interactions between matrix …

Alzheimer's disease: How metal ions define β-amyloid function

KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …