Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease.
Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Extracellular matrix (ECM) deposition during wound healing is a physiological response to
an insult. Wound healing becomes deregulated in the setting of chronic injury or long …

Pulmonary hypertension (PH) is a chronic and disabling condition that affects the pulmonary
vasculature. Once PH is diagnosed, the prognosis is generally poor with a rapid downhill …

Obesity potentiates the severity of alcohol-induced liver damage. Ethanol influences
adipose tissue production of hormones and cytokines. The mechanisms by which adiposity …

Cardiac development and function require actin–myosin interactions in the sarcomere, a
highly organized contractile structure. Sarcomere assembly mediated by formin homology 2 …

The end-stage of the clinical combination of heart failure and kidney disease has become
known as cardiorenal syndrome. Adverse consequences related to diabetes …

Background Catecholamines have been shown to aggravate atherosclerosis in animals and
humans, and abnormal proliferation of vascular smooth muscle cells (VSMC) is a key event …

Although increased deposition of collagen proteins has been described after myocardial
infarction (MI), little is known of timedependent transcriptional alteration of specific cardiac …