Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases
that lack therapeutic solutions. Here, we show that the molecular chaperone (N, N …

In this work, the ab initio fragment molecular orbital (FMO) method was applied to calculate
and analyze the binding energy of two biscarbene-Au (I) derivatives,[Au (9-methylcaffein-8 …

Ligands such as enzyme inhibitors stabilize the native conformation of a protein upon
binding to the native state, but some compounds destabilize the native conformation upon …

A number of previous successful attempts in the search for therapeutics for a variety of
human pathologies highlight the importance of computational technologies in the drug …

A conformational change from normal prion protein (PrPC) to abnormal prion protein
(PrPSC) induces fatal neurodegenerative diseases. Acidic pH is well-known factors involved …

Pygopus2 (Pygo2) is a component of the Wnt signaling pathway, which is required for β‐
catenin mediated transcription. Plant homeodomain (PHD) finger in Pygo2 intercalates the …

Introduction: To date, various therapeutic strategies identified numerous anti-prion
compounds and antibodies that stabilize PrPC, block the conversion of PrPC-PrPSc and …

A designer chaperone against prion diseases | Nature Biomedical Engineering Skip to main
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Autophagy induction in tumors is implicated in tumor malignancy and acquisition of
anticancer-drug resistance, and hence, autophagy inhibitors are expected as novel …