A comparison of different machine-learning techniques for the selection of a panel of metabolites allowing early detection of brain tumors

A Godlewski, M Czajkowski, P Mojsak, T Pienkowski… - Scientific Reports, 2023 - nature.com
Metabolomics combined with machine learning methods (MLMs), is a powerful tool for
searching novel diagnostic panels. This study was intended to use targeted plasma …

Integrating Multi-Omics analysis for enhanced diagnosis and treatment of glioblastoma: A comprehensive Data-Driven approach

A Barzegar Behrooz, H Latifi-Navid, SC da Silva Rosa… - Cancers, 2023 - mdpi.com
Simple Summary The most prevalent and lethal primary brain tumor, glioblastoma
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …

Assessing metabolic markers in glioblastoma using machine learning: a systematic review

ZD Neil, N Pierzchajlo, C Boyett, O Little, CC Kuo… - Metabolites, 2023 - mdpi.com
Glioblastoma (GBM) is a common and deadly brain tumor with late diagnoses and poor
prognoses. Machine learning (ML) is an emerging tool that can create highly accurate …

Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation

S Ibrahim, MU Khan, S Noreen, S Firdous, I Khurram… - Cytotechnology, 2025 - Springer
The long-term treatment of malignancies, particularly brain tumors, is challenged by
abnormal protein expression and drug resistance. In terms of potency, selectivity, and …

Urinary D-asparagine level is decreased by the presence of glioblastoma

Y Nakade, M Kinoshita, M Nakada, H Sabit… - Acta Neuropathologica …, 2024 - Springer
Abstract Gliomas, particularly glioblastomas (GBMs), pose significant challenges due to their
aggressiveness and poor prognosis. Early detection through biomarkers is critical for …

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled l-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection

K Li, AL Gilberti, JA Marden, HK Akula… - Journal of Medicinal …, 2024 - ACS Publications
To fully explore the potential of 18F-labeled l-fluoroalanine for imaging cancer and other
chronic diseases, a simple and mild radiosynthesis method has been established to …

MALDI-MSI-LC-MS/MS Workflow for Single-Section Single Step Combined Proteomics and Quantitative Lipidomics

TFE Hendriks, KK Krestensen, R Mohren… - Analytical …, 2024 - ACS Publications
We introduce a novel approach for comprehensive molecular profiling in biological samples.
Our single-section methodology combines quantitative mass spectrometry imaging (Q-MSI) …

PiDeeL: metabolic pathway-informed deep learning model for survival analysis and pathological classification of gliomas

G Kaynar, D Cakmakci, C Bund, J Todeschi… - …, 2023 - academic.oup.com
Motivation Online assessment of tumor characteristics during surgery is important and has
the potential to establish an intra-operative surgeon feedback mechanism. With the …

Integrating HRMAS-NMR Data and Machine Learning-Assisted Profiling of Metabolite Fluxes to Classify Low-and High-Grade Gliomas

S Firdous, Z Nawaz, R Abid, LL Cheng… - Interdisciplinary …, 2024 - Springer
Diagnosing and classifying central nervous system tumors such as gliomas or glioblastomas
pose a significant challenge due to their aggressive and infiltrative nature. However, recent …

Targeted metabolomics analyses for brain tumor margin assessment during surgery

D Cakmakci, G Kaynar, C Bund, M Piotto… - …, 2022 - academic.oup.com
Motivation Identification and removal of micro-scale residual tumor tissue during brain tumor
surgery are key for survival in glioma patients. For this goal, High-Resolution Magic Angle …