Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Abstract Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative
degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in …

During legume-rhizobia symbiosis, differentiation of the symbiosome (engulfed intracellular
rhizobia) is necessary for successful nitrogen fixation. To control symbiosome differentiation …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

The ubiquitin proteasome system (UPS) maintains the integrity of the proteome by
selectively degrading misfolded or mis-assembled proteins, but the rules that govern how …

Numerous nascent proteins undergo folding and maturation within the luminal and
membrane compartments of the endoplasmic reticulum (ER). Despite the presence of …

The biosynthesis of thousands of proteins requires targeting a signal sequence or
transmembrane segment (TM) to the endoplasmic reticulum (ER). These hydrophobic ɑ …