Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

Life begins with a switch in genetic control from the maternal to the embryonic genome
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

The development of the ovarian follicle to its culmination by ovulation is an essential
element of fertility. The final stages of ovarian follicular growth are characterized by …

The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the
action of an interconnected network of transcription factors. Among them, only Oct4 and …

In rodents, the naïve early epiblast undergoes profound morphogenetic, transcriptional and
epigenetic changes after implantation. These differences are maintained between blastocyst …

The orphan nuclear receptor NR5A2 is necessary for the stem-like properties of the epiblast
of the pre-gastrulation embryo and for cellular and physiological homeostasis of endoderm …

Successful pregnancy requires coordination of an array of signals and factors from multiple
tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor …

Early embryogenesis is driven by transcription factors (TFs) that first activate the zygotic
genome and then specify the lineages constituting the blastocyst. Although the TFs …