Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in~ 70% of
breast cancers. Class I PI3K generates PtdIns (3, 4, 5) P3 at the plasma membrane in …

Genetic studies revealed that SHIP1 limits blood cell production and immune regulatory cell
numbers in vivo. We postulated that molecular targeting of SHIP1 might enhance blood cell …

Many tumors present with increased activation of the phosphatidylinositol 3-kinase (PI3K)-
PtdIns (3, 4, 5) P 3-protein kinase B (PKB/Akt) signaling pathway. It has long been thought …

Metastasis is the leading cause of death for non‐small cell lung cancer (NSCLC) patients.
However, how lung cancer cells invade blood vessels during metastasis remains unclear …

Simple Summary Phosphoinositol signaling pathways and their dysregulation have been
shown to have a fundamental role in health and disease, respectively. The SH2-containing …

Phosphoinositide signalling molecules interact with a plethora of effector proteins to regulate
cell proliferation and survival, vesicular trafficking, metabolism, actin dynamics and many …

In cancer, deregulated signaling can produce an invasive cellular phenotype. We modeled
the invasive transition as a theoretical switch between two cytoskeletal structures: focal …

Oxysterol-binding protein-related proteins (ORPs) form a large family of intracellular lipid
binding/transfer proteins. A number of ORPs are implicated in inter-organelle lipid transfer …