DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …

In the past years, several lines of evidence have shown that cell cycle regulatory proteins
also can modulate metabolic processes. The transcription factor E2F1 is a central player …

The DNA-methylating drug temozolomide, which induces cell death through apoptosis, is
used for the treatment of malignant glioma. Here, we investigate the mechanisms underlying …

Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

NF-κB regulates the expression of a large number of target genes involved in the immune
and inflammatory response, apoptosis, cell proliferation, differentiation and survival. In this …

The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB)
pathway and are required for the timely regulation of numerous genes essential for DNA …

The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket
protein'family of cell cycle regulators. These proteins are best known for their roles in …

Coinfections with pathogenic microbes continually confront cervical mucosa, yet their
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …

Short interfering RNA (siRNA) is widely used for studying gene function and holds great
promise as a tool for validating drug targets and treating disease. A critical assumption in …

Hypoxia and nutrient deprivation are environmental stresses governing the survival and
adaptation of tumor cells in vivo. We have identified a novel role for the Rb tumor suppressor …