Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …

Familial idiopathic nephrotic syndromes represent a heterogeneous group of kidney
disorders, and include autosomal recessive steroid-resistant nephrotic syndrome, which is …

The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …

The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs)
are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process …

One of the most dominant influences in the patterning of multicellular embryos is exerted by
the Hedgehog (Hh) family of secreted signaling proteins. Here, we identify a segment …

Due to its presumed role in regulating cellular cholesterol homeostasis, and in various
pathophysiological conditions, acyl-coenzyme A: cholesterol acyltransferase (ACAT) has …

Triglycerides and cholesterol are important biological lipids, and their excessive intake in the
diet is relevant to the development of two prevalent cardiovascular risk factors, obesity and …

A family of mammalian protocadherin (Pcdh) proteins is encoded by three closely linked
gene clusters (α, β, and γ). Multiple α and γ Pcdh mRNAs are expressed in distinct patterns …

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that
produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and …