Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Stroke is the second leading cause of global death and is characterized by high rates of
mortality and disability. Oxidative stress is accompanied by other pathological processes …

Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …

Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects
thousands of human beings, and the pathologic changes after injury have been a hot spot …

Alzheimer's disease (AD) is a heterogeneous disease with complex clinicopathological
characteristics. To date, the role of m6A RNA methylation in monocyte-derived macrophages …