Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity

H Zhang, J Vandesompele, K Braeckmans… - Chemical Society …, 2024 - pubs.rsc.org
Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …

Light-emitting diodes for analytical chemistry

M Macka, T Piasecki… - Annual Review of …, 2014 - annualreviews.org
Light-emitting diodes (LEDs) are playing increasingly important roles in analytical chemistry,
from the final analysis stage to photoreactors for analyte conversion to actual fabrication of …

Analysis of therapeutic nucleic acids by capillary electrophoresis

B Wei, A Goyon, K Zhang - Journal of Pharmaceutical and Biomedical …, 2022 - Elsevier
Nucleic acids are getting increased attention to fulfill unmet medical needs. The past five
years have seen more than ten FDA approvals of nucleic acid based therapeutics. New …

Light emitting diodes (LEDs) in fluorescence-based analytical applications: A review

DC Mukunda, VK Joshi, KK Mahato - Applied Spectroscopy …, 2022 - Taylor & Francis
In recent times, fluorescence-based analytical devices are getting more equipped with LEDs
than conventional light sources because of their availability in a broad range of wavelengths …

Oligonucleotide separation techniques for purification and analysis: What can we learn for today's tasks?

R Minkner, J Boonyakida, EY Park, H Wätzig - Electrophoresis, 2022 - Wiley Online Library
Nucleic acids are the blueprint of life. They are not only the construction plan of the single
cell or higher associations of them, but also necessary for function, communication and …

Pulmonary delivery of mRNA

BC Guild, F DeRosa, M Heartlein - US Patent 9,597,413, 2017 - Google Patents
US9597413B2 - Pulmonary delivery of mRNA - Google Patents US9597413B2 - Pulmonary
delivery of mRNA - Google Patents Pulmonary delivery of mRNA Download PDF Info Publication …

Lipid nanoparticle compositions and methods for MRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,238,754, 2019 - Google Patents
US10238754B2 - Lipid nanoparticle compositions and methods for MRNA delivery - Google
Patents US10238754B2 - Lipid nanoparticle compositions and methods for MRNA delivery …

Portable RT-PCR system: a rapid and scalable diagnostic tool for COVID-19 testing

HM Zowawi, TH Alenazi, WS AlOmaim… - Journal of clinical …, 2021 - Am Soc Microbiol
Combating the ongoing coronavirus disease 2019 (COVID-19) pandemic demands
accurate, rapid, and point-of-care testing with fast results to triage cases for isolation and …

Lipid nanoparticle compositions and methods for mRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,413,618, 2019 - Google Patents
US10413618B2 - Lipid nanoparticle compositions and methods for mRNA delivery - Google
Patents US10413618B2 - Lipid nanoparticle compositions and methods for mRNA delivery …

Lipid nanoparticle compositions and methods for mRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,350,303, 2019 - Google Patents
US10350303B1 - Lipid nanoparticle compositions and methods for mRNA delivery - Google
Patents US10350303B1 - Lipid nanoparticle compositions and methods for mRNA delivery …