CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Principles of regulatory T cell function
S Dikiy, AY Rudensky - Immunity, 2023 - cell.com
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …
Pan-cancer single-cell landscape of tumor-infiltrating T cells
INTRODUCTION Cancer immunotherapies that target tumor-specific T cells have benefited
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment
Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
Within the tumour microenvironment, CD4+ T cells can promote or suppress antitumour
responses through the recognition of antigens presented by human leukocyte antigen (HLA) …
responses through the recognition of antigens presented by human leukocyte antigen (HLA) …
[HTML][HTML] Intratumoral CD4+ T cells mediate anti-tumor cytotoxicity in human bladder cancer
Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …
[HTML][HTML] Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
Y Zheng, Z Chen, Y Han, L Han, X Zou, B Zhou… - Nature …, 2020 - nature.com
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the
comprehensive understanding of the immune landscape of the tumor microenvironment …
comprehensive understanding of the immune landscape of the tumor microenvironment …
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
Y Kidani, W Nogami, Y Yasumizu… - Proceedings of the …, 2022 - National Acad Sciences
Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
[HTML][HTML] Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Human T cells coordinate adaptive immunity in diverse anatomic compartments through
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Y Togashi, K Shitara, H Nishikawa - Nature reviews Clinical oncology, 2019 - nature.com
Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …