Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight
loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is …

Current policy and research around type 2 diabetes (T2D) interventions largely invoke a
behavioral model. We suggest that activation of the physiologic stress response (PSR) from …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

Peripheral inflammation induces transmigration of interleukin (IL)-1β-expressing neutrophils
to the brain. We investigated the possibility that this presents a new route of immune-to-brain …

Major depression is common in the context of autoimmune and inflammatory diseases and
is frequently associated with persistently raised levels of proinflammatory cytokines and …

To gain insight into the possible immune targets of antidepressant, we evaluated the
expression of several inflammatory mediators in the hypothalamus of rats chronically (28 …

Research has shown that inflammatory processes affect brain function and behavior through
several neuroimmune pathways. However, high order brain functions affected by …

Background Kinin B 1 receptors are inducible molecules up-regulated after inflammatory
stimuli. This study evaluated the relevance of kinin B 1 receptors in a mouse depression …

Inflammatory diseases are highly associated with affective disorders including depression
and anxiety. While the role of the innate immune system on emotionality has been …