Natural killer T-like cells: immunobiology and role in disease

JS Almeida, JM Casanova, M Santos-Rosa… - International Journal of …, 2023 - mdpi.com
CD56+ T cells are generally recognized as a distinct population of T cells and are
categorized as NKT-like cells. Although our understanding of NKT-like cells is far from …

NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics

Y Choi, WAA Saron, A O'Neill, M Senanayake… - The Journal of Clinical …, 2024 - jci.org
NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their
contributions to long-term immune memory to viruses are unclear. We identified granzyme K …

Subpopulation dynamics of T and B lymphocytes in Sjögren's syndrome: implications for disease activity and treatment

Q Meng, J Ma, J Cui, Y Gu, Y Shan - Frontiers in Immunology, 2024 - frontiersin.org
Sjögren's syndrome (SS) is an autoimmune disorder primarily affecting the body's exocrine
glands, particularly the salivary and lacrimal glands, which lead to severe symptoms of dry …

Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability

JA Burke, X Zhang, S Bobbala, MA Frey… - Nature …, 2022 - nature.com
Standard oral rapamycin (that is, Rapamune) administration is plagued by poor
bioavailability and broad biodistribution. Thus, this pleotropic mammalian target of …

Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity

K Lambert, KG Moo, A Arnett, G Goel, A Hu… - Science translational …, 2022 - science.org
Individuals with Down syndrome show cellular and clinical features of dysregulated aging of
the immune system, including a shift from naïve to memory T cells and increased incidence …

IL-15 upregulates telomerase expression and potently increases proliferative capacity of NK, NKT-like, and CD8 T cells

F Watkinson, SK Nayar, A Rani… - Frontiers in …, 2021 - frontiersin.org
Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural
killer (NK) cell populations, and therefore has potential for potentiating adoptive immune cell …

Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells

Y Chen, B Jiang, C Qu, C Jiang, C Zhang… - Frontiers in …, 2024 - frontiersin.org
Introduction We aimed to comprehensively investigate the causal relationship between 731
immune cell traits and autoimmune thyroiditis (AIT) and to identify and quantify the role of …

Noninvasive low-frequency pulsed focused ultrasound therapy for rheumatoid arthritis in mice

X Hu, F Li, J Zeng, Z Zhou, Z Wang, J Chen, D Cao… - Research, 2022 - spj.science.org
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic and
progressive inflammation of the synovium. Focused ultrasound therapy is an increasingly …

[HTML][HTML] Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection

W Zhang, Z Yi, C Wei, KL Keung, Z Sun, C Xi… - JCI insight, 2019 - ncbi.nlm.nih.gov
Commonly available clinical parameters fail to predict early acute cellular rejection (EAR,
occurring within 6 months after transplant), a major risk factor for graft loss after kidney …

Mouse CD8+NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells

Z Li, Y Wu, C Wang, M Zhang - Cancer Immunology, Immunotherapy, 2019 - Springer
Our previous work has demonstrated the high efficiency of CD8+ natural killer T (NKT)-like
cells in killing antigen-bearing dendritic cells. To evaluate their role in the tumor …