Sustained access to nutrients is a fundamental biological need, especially for proliferating
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …

FcγRIIB is the only inhibitory Fc receptor. It controls many aspects of immune and
inflammatory responses, and variation in the gene encoding this protein has long been …

Detection of intracellular DNA triggers activation of the STING-dependent interferon-
stimulatory DNA (ISD) pathway, which is essential for antiviral responses. Multiple DNA …

Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells,
represent a specialized cell type within the innate immune system. pDCs are specialized in …

Purpose Lupus nephritis, a major cause of morbidity in patients with systemic lupus
erythematosus (SLE), is generally thought to be induced by macrophage-mediated …

Autoimmune diseases are characterized by adaptive immune responses against self‐
antigens, including humoral responses resulting in the production of autoantibodies …

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …

Systemic lupus erythematosus (SLE) in patients and certain mouse models exhibits a strong
sex bias. Additionally, in most patients, increased serum levels of type I interferon (IFN-α) are …

Objective—B-cell depletion therapy is widely used for treatment of cancers and autoimmune
diseases. B cells are abundant in abdominal aortic aneurysms (AAA); however, it is …

Mouse models of SLE have been indispensable tools to study disease pathogenesis, to
identify genetic susceptibility loci and targets for drug development, and for preclinical …