[HTML][HTML] Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts

MJ Shears, CY Botté, GI McFadden - Molecular and biochemical …, 2015 - Elsevier
The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

PK Boniface, EI Ferreira - Phytotherapy Research, 2019 - Wiley Online Library
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

Targeting the liver stage of malaria parasites: a yet unmet goal

T Rodrigues, M Prudêncio, R Moreira… - Journal of medicinal …, 2012 - ACS Publications
Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …

Triclosan and triclosan-loaded liposomal nanoparticles in the treatment of acute experimental toxoplasmosis

LA El-Zawawy, D El-Said, SF Mossallam… - Experimental …, 2015 - Elsevier
Efficacy of triclosan (TS) and TS-loaded liposomes against the virulent strain of Toxoplasma
gondii (T. gondii) was evaluated. Swiss albino mice were intraperitoneally infected with 10 4 …

[HTML][HTML] Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan

E Bilsland, L Van Vliet, K Williams, J Feltham… - Scientific Reports, 2018 - nature.com
Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths
per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes …

Antiprotozoal Steroidal Saponins from the Marine Sponge Pandaros acanthifolium

EL Regalado, D Tasdemir, M Kaiser… - Journal of natural …, 2010 - ACS Publications
The chemical composition of the Caribbean sponge Pandaros acanthifolium was
reinvestigated and led to the isolation of 12 new steroidal glycosides, namely, pandarosides …

Structure-based design and pharmacophore-based virtual screening of combinatorial library of triclosan analogues active against enoyl-acyl carrier protein reductase …

C Bieri, A Esmel, M Keita, LCO Owono, B Dali… - International Journal of …, 2023 - mdpi.com
Cost-effective therapy of neglected and tropical diseases such as malaria requires
everlasting drug discovery efforts due to the rapidly emerging drug resistance of the …

Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes

M Orsi, MG Noro, JW Essex - Journal of the Royal …, 2011 - royalsocietypublishing.org
Triclocarban and triclosan, two potent antibacterial molecules present in many consumer
products, have been subject to growing debate on a number of issues, particularly in relation …

Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target

IL Lauinger, L Vivas, R Perozzo… - Journal of natural …, 2013 - ACS Publications
Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal
prophylaxis of malaria. In this study, four lichen metabolites, evernic acid (1), vulpic acid (2) …

Assessment of dual life stage antiplasmodial activity of british seaweeds

J Spavieri, A Allmendinger, M Kaiser, MA Itoe… - Marine Drugs, 2013 - mdpi.com
Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial
drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of …