Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Hydroxynorketamines (HNKs) are formed in vivo after (R, S)-ketamine (ketamine)
administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl …

Ketamine is a phencyclidine derivative and a non-competitive antagonist of N-methyl-D-
aspartate (NMDA) receptor for which glutamate is the full agonist. It produces a functional …

Background (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal
models of depression. It is stereoselectively metabolized to (R)-norketamine and …

The effect of the (R, S)-ketamine metabolites (R, S)-norketamine,(R, S)-
dehydronorketamine,(2S, 6S)-hydroxynorketamine and (2R, 6R)-hydroxynorketamine on the …

Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of
clinical practice and scientific inquiry. From anesthesia and analgesia to depression and …

Background Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts robust
antidepressant effects in patients with treatment-resistant depression. The precise …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT•(R, S)‐ketamine is a phencyclidine
derivative that was initially developed as an anaesthetic agent and which is currently being …

Herein, a straightforward electrochemical approach for the determination of ketamine in
street samples and seizures is presented by employing screen-printed electrodes (SPE) …

The objective was to determine the cytochrome P450s (CYPs) responsible for the
stereoselective and regiospecific hydroxylation of ketamine [(R, S)-Ket] to diastereomeric …