Piezoelectric effect produces an electrical signal when stress is applied to the bone. When
the integrity of the bone is destroyed, the biopotential within the defect site is reduced and …

In this article, we provide an extensive review of the recent literature of the signaling
pathways modulated by Pulsed Electromagnetic Fields (PEMFs) and PEMFs clinical …

Mesenchymal stem cells (MSCs) are the main cell players in tissue repair and thanks to their
self-renewal and multi-lineage differentiation capabilities, they gained significant attention …

Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems
and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation …

Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe
physical therapy strategy to accelerate bone repair has received tremendous attention in …

The US FDA has approved pulsed electromagnetic fields (PEMFs) as a safe and effective
treatment for nonunions of bone. Despite its clinical use, the mechanisms of action of …

Tissue engineering-based bone graft is an emerging viable treatment modality to repair and
regenerate tissues damaged as a result of diseases or injuries. The structure and …

Mesenchymal stem cells (MSCs) play a major role in bone tissue engineering (BTE) thanks
to their capacity for osteogenic differentiation and being easily available. In vivo, MSCs are …

Impaired apoptosis is one of the hallmarks of cancer, and almost all of the non‐surgical
approaches of eradicating tumour cells somehow promote induction of apoptosis. Indeed …

Stem cell fate can be directed through the application of various external physical stimuli,
enabling a controlled approach to targeted differentiation. Studies involving the use of …