Fibrosis is a pathological process that affects multiple organs and is considered one of the
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …

Copper is an essential trace element in the human body that is extensively distributed
throughout various tissues. The appropriate level of copper is crucial to maintaining the life …

Objective Cuproptosis is a newly discovered form of programmed cell death that has not
been studied in pulmonary fibrosis. The purpose of the present study was to explore the …

Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM)
homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic …

Hypertrophic scar (HS) is a chronic inflammatory skin disease characterized by excessive
deposition of extracellular matrix, but the exact mechanisms related to its formation remain …

Vitamin C (ascorbic acid; AA) and copper (Cu2+) are well used supplements with many
health-promoting actions. However, when they are used in combination, the Fenton reaction …

Introduction: In chronic kidney disease, proteinuria increases urinary copper excretion,
inducing oxidative tubular damage and worsening kidney function. We investigated whether …

Programmed cell death of renal tubular epithelial cells (RTECs) is the main
pathophysiological mechanism of acute kidney injury (AKI). Copper-induced death is a …

Background: Vitamin C deficiency is associated with excess mortality in kidney transplant
recipients (KTR). We investigated its prevalence at various time-points post transplantation …

Background: In chronic kidney disease, proteinuria increases urinary copper excretion,
inducing oxidative tubular damage and worsening kidney function. We investigated whether …