The synapsins: key actors of synapse function and plasticity
The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
Chemistry and pharmacology of GABAB receptor ligands
W Froestl - Advances in pharmacology, 2010 - Elsevier
This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …
Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors
W Froestl, A Muhs, A Pfeifer - Journal of Alzheimer's disease, 2012 - content.iospress.com
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …
The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer's disease development: biomarkers and preventive strategies
AK Kapila, HR Watts, T Wang… - Journal of Alzheimer's …, 2014 - content.iospress.com
Alzheimer's disease (AD) is a major social and clinical burden in the elderly, affecting 5% of
people aged over 65 and 20% aged over 80. Despite improved management, a cure has not …
people aged over 65 and 20% aged over 80. Despite improved management, a cure has not …
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib
JM Revest, N Kaouane, M Mondin, A Le Roux… - Molecular …, 2010 - nature.com
The activation of glucocorticoid receptors (GR) by glucocorticoids increases stress-related
memory through the activation of the MAPK signaling pathway and the downstream …
memory through the activation of the MAPK signaling pathway and the downstream …
Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate
The aim of the present study was to examine the roles of l-fucose and the
glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate …
glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate …
[HTML][HTML] 7, 8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery
Metabolic dysfunction accompanying traumatic brain injury (TBI) severely impairs the ability
of injured neurons to comply with functional demands. This limits the success of …
of injured neurons to comply with functional demands. This limits the success of …
[HTML][HTML] Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule
Adult neurogenesis occurs throughout life in the mammalian hippocampus and is essential
for memory and mood control. There is significant interest in identifying ways to promote …
for memory and mood control. There is significant interest in identifying ways to promote …
Historical perspective and emergence of the GABAB receptor
NG Bowery - Advances in pharmacology, 2010 - Elsevier
This chapter forms an introduction to the subsequent chapters in this volume which highlight
the significance and potential therapeutic application of GABA B receptors. It is now 30 years …
the significance and potential therapeutic application of GABA B receptors. It is now 30 years …